Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 7/20 | 0.52 |
| ▸ | HRH1 | P35367 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | CALCA | P06881 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | UGCG | Q16739 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14435971 | 0.95 | HRH2 (0.48) | HRH2HRH1KMT2AMAPK1MC4R | |
| SCHEMBL14431445 | 0.91 | MC4R (0.51) | HRH2HRH1MC4RCALCAKDM4E | |
| SCHEMBL14435629 | 0.90 | HRH2 (0.46) | HRH2HRH1KMT2AMAPK1MC4R | |
| SCHEMBL14431339 | 0.88 | HRH2 (0.46) | HRH2HRH1KMT2AMAPK1MC4R | |
| SCHEMBL14431091 | 0.88 | HRH2 (0.51) | HRH2HRH1KMT2AMAPK1MC4R | |
| SCHEMBL14431138 | 0.88 | HRH2 (0.48) | HRH2HRH1KMT2AMAPK1MC4R | |
| SCHEMBL12738196 | 0.87 | MC4R (0.52) | HRH2HRH1KMT2AMAPK1MC4R | |
| SCHEMBL14435972 | 0.86 | KMT2A (0.47) | HRH2HRH1KMT2AMAPK1MC4R | |
| SCHEMBL12737362 | 0.86 | MC4R (0.45) | HRH2HRH1KMT2AMAPK1MC4R | |
| SCHEMBL12737691 | 0.85 | MC4R (0.44) | HRH2HRH1KMT2AMAPK1MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096186-A1 | SUBSTITUTED PHENYLPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2007-08-30 | — | — | WO | disclosed |
| EP-1826201-A1 | Substituted phenylpiperidine derivatives as melanocortin-4 receptor modulators | Santhera Pharmaceuticals (Schweiz) AG (CH) | 2007-08-29 | — | — | EP | disclosed |