Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.65 |
| ▸ | TP53 | P04637 | 6/20 | 0.65 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | GRM6 | O15303 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13815985 | 0.86 | TP53 (0.66) | SMN1; SMN2TP53MAPTPOLBGAA | |
| SCHEMBL6256682 | 0.77 | POLB (0.60) | SMN1; SMN2TP53MAPTPOLBGAA | |
| SCHEMBL9269085 | 0.77 | HTT (0.59) | SMN1; SMN2TP53MAPTPOLBGAA | |
| SCHEMBL9695395 | 0.74 | POLB (0.56) | SMN1; SMN2TP53MAPTPOLBGAA | |
| SCHEMBL6256516 | 0.73 | POLB (0.55) | SMN1; SMN2TP53MAPTPOLBGAA | |
| SCHEMBL9273102 | 0.73 | POLB (0.52) | SMN1; SMN2TP53MAPTPOLBGAA | |
| SCHEMBL13615444 | 0.73 | POLB (0.58) | SMN1; SMN2TP53MAPTPOLBGAA | |
| SCHEMBL2775071 | 0.73 | GAA (0.64) | SMN1; SMN2POLBGAAGRM6HTT | |
| SCHEMBL6257634 | 0.72 | MAPT (0.59) | SMN1; SMN2TP53MAPTPOLBGAA | |
| SCHEMBL8806215 | 0.72 | GAA (0.53) | SMN1; SMN2TP53MAPTPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |