Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 5/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13449494 | 0.83 | TDP1 (0.54) | TDP1MAPTALDH1A1HPGDLMNA | |
| SCHEMBL751103 | 0.83 | TDP1 (0.54) | TDP1MAPTALDH1A1HPGDLMNA | |
| SCHEMBL751104 | 0.83 | TDP1 (0.54) | TDP1MAPTALDH1A1HPGDLMNA | |
| SCHEMBL29156222 | 0.78 | TDP1 (0.53) | TDP1MAPTALDH1A1HPGDLMNA | |
| SCHEMBL29156225 | 0.78 | TDP1 (0.53) | TDP1MAPTALDH1A1HPGDLMNA | |
| SCHEMBL13221154 | 0.77 | TDP1 (0.62) | TDP1MAPTALDH1A1HPGDLMNA | |
| SCHEMBL678566 | 0.77 | TDP1 (0.62) | TDP1MAPTALDH1A1HPGDLMNA | |
| SCHEMBL6977513 | 0.77 | TDP1 (0.62) | TDP1MAPTALDH1A1HPGDLMNA | |
| SCHEMBL24759814 | 0.75 | TDP1 (0.50) | TDP1MAPTALDH1A1HPGDLMNA | |
| SCHEMBL17361336 | 0.75 | TDP1 (0.50) | TDP1MAPTALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096334-A1 | PYRROLOPYRROLONES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2007-08-30 | — | — | WO | disclosed |