Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.63 |
| ▸ | GCK | P35557 | 16/20 | 0.60 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2641959 | 1.00 | KCNH2 (0.63) | KCNH2GCKFFAR2 | |
| SCHEMBL14423153 | 1.00 | KCNH2 (0.63) | KCNH2GCKFFAR2 | |
| SCHEMBL2642342 | 1.00 | KCNH2 (0.63) | KCNH2GCKFFAR2 | |
| SCHEMBL2642077 | 0.95 | GCK (0.63) | KCNH2GCKFFAR2 | |
| SCHEMBL2642074 | 0.95 | GCK (0.63) | KCNH2GCKFFAR2 | |
| SCHEMBL14423144 | 0.95 | GCK (0.63) | KCNH2GCKFFAR2 | |
| SCHEMBL2642082 | 0.92 | KCNH2 (0.64) | KCNH2GCKFFAR2 | |
| SCHEMBL2642084 | 0.92 | KCNH2 (0.64) | KCNH2GCKFFAR2 | |
| SCHEMBL2642212 | 0.92 | KCNH2 (0.64) | KCNH2GCKFFAR2 | |
| SCHEMBL2642211 | 0.92 | KCNH2 (0.64) | KCNH2GCKFFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259166-B2 | Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2007-08-21 | — | — | US | disclosed |