Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 13/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | UGCG | Q16739 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 4/20 | 0.39 |
| ▸ | MC5R | P33032 | 2/20 | 0.39 |
| ▸ | MC1R | Q01726 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CALCA | P06881 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14431084 | 0.95 | MC4R (0.53) | MC4RCYP3A4UGCGHRH2HRH1 | |
| SCHEMBL14431085 | 0.92 | MC4R (0.42) | MC4RHRH2HRH1PABPC1SCN9A | |
| SCHEMBL14431450 | 0.91 | HRH2 (0.46) | MC4RHRH2HRH1PABPC1SCN9A | |
| SCHEMBL14431138 | 0.87 | HRH2 (0.48) | MC4RCYP3A4UGCGHRH2HRH1 | |
| SCHEMBL14431445 | 0.86 | MC4R (0.51) | MC4RCYP3A4UGCGHRH2HRH1 | |
| SCHEMBL12713282 | 0.85 | MC4R (0.42) | MC4RCYP3A4UGCGMC3RMC5R | |
| SCHEMBL12738196 | 0.84 | MC4R (0.52) | MC4RCYP3A4UGCGHRH2HRH1 | |
| SCHEMBL12738097 | 0.83 | MC4R (0.55) | MC4RCYP3A4UGCGHRH2HRH1 | |
| SCHEMBL12713143 | 0.83 | MC4R (0.47) | MC4RCYP3A4UGCGMC3RMC5R | |
| SCHEMBL14435563 | 0.83 | HDAC8 (0.48) | MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096186-A1 | SUBSTITUTED PHENYLPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2007-08-30 | — | — | WO | disclosed |