Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 14/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3140667 | 0.98 | PIK3CA (0.66) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3141797 | 0.95 | PIK3CA (0.68) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3132912 | 0.90 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL14436297 | 0.88 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL14436801 | 0.86 | PIK3CA (0.73) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL14436408 | 0.85 | PIK3CA (0.67) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3141057 | 0.85 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3142113 | 0.85 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL14436382 | 0.84 | PIK3CA (0.78) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3150768 | 0.84 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007095588-A1 | PI-3 KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2007-08-23 | — | — | WO | disclosed |