Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | ARNT | P27540 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14437272 | 0.89 | CISD1 (0.41) | CISD1MEN1KMT2AGAAALOX5 | |
| SCHEMBL5508740 | 0.87 | CISD1 (0.36) | CISD1MEN1KMT2AGAASLC2A1 | |
| SCHEMBL3868501 | 0.83 | CISD1 (0.41) | CISD1MEN1KMT2AGAAALOX5 | |
| SCHEMBL13897380 | 0.83 | CISD1 (0.41) | CISD1MEN1KMT2AGAAALOX5 | |
| SCHEMBL3868504 | 0.83 | CISD1 (0.41) | CISD1MEN1KMT2AGAAALOX5 | |
| SCHEMBL14437276 | 0.82 | CISD1 (0.40) | CISD1MEN1KMT2AGAAALOX5 | |
| SCHEMBL5505342 | 0.81 | CISD1 (0.48) | CISD1MEN1KMT2AGAAALOX5 | |
| SCHEMBL14437310 | 0.81 | CISD1 (0.48) | CISD1MEN1KMT2AGAAALOX5 | |
| SCHEMBL5505339 | 0.81 | CISD1 (0.48) | CISD1MEN1KMT2AGAAALOX5 | |
| SCHEMBL14437200 | 0.80 | MEN1 (0.41) | CISD1MEN1KMT2AGAAALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253285-B2 | Thiazolinone 4-monosubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253285-B2 | Thiazolinone 4-monosubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |