Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.68 |
| ▸ | RET | P07949 | 6/20 | 0.68 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.68 |
| ▸ | KIT | P10721 | 3/20 | 0.68 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.68 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.68 |
| ▸ | FLT1 | P17948 | 2/20 | 0.68 |
| ▸ | FLT4 | P35916 | 2/20 | 0.68 |
| ▸ | ABL1 | P00519 | 2/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.68 |
| ▸ | ERN1 | O75460 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.68 |
| ▸ | ESR1 | P03372 | 1/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
| ▸ | BCR | P11274 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL864039 | 0.89 | KDR (0.69) | KDRRETFGFR4PDGFRAAURKB | |
| SCHEMBL864156 | 0.89 | FGFR4 (0.85) | KDRRETFGFR4PDGFRAAURKB | |
| SCHEMBL14693157 | 0.89 | FGFR4 (0.61) | KDRRETFGFR4PDGFRAAURKB | |
| SCHEMBL25779446 | 0.86 | KDR (0.80) | KDRRETFGFR4PDGFRAAURKB | |
| SCHEMBL863807 | 0.86 | AXL (0.69) | KDRRETFGFR4PDGFRAAURKB | |
| SCHEMBL14437494 | 0.86 | FGFR4 (0.65) | KDRRETFGFR4PDGFRAAURKB | |
| SCHEMBL14437868 | 0.85 | FGFR4 (0.63) | KDRRETFGFR4PDGFRAAURKB | |
| SCHEMBL14437500 | 0.85 | KDR (0.63) | KDRRETFGFR4PDGFRAAURKB | |
| SCHEMBL14693165 | 0.84 | FGFR4 (0.59) | KDRRETFGFR4PDGFRAAURKB | |
| SCHEMBL14693169 | 0.82 | KDR (0.58) | KDRRETFGFR4PDGFRAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253286-B2 | Urea derivatives containing aromatic or heteroaromatic rings, useful as prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI CO., LTD (JP) | 2007-08-07 | — | — | US | disclosed |