Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14446240 | 0.89 | POLB (0.45) | POLBMEN1TSHRHTTKMT2A | |
| SCHEMBL5158894 | 0.89 | KDM1A (0.37) | POLBMEN1TSHRHTTKMT2A | |
| SCHEMBL5161131 | 0.89 | KDM1A (0.37) | POLBMEN1TSHRHTTKMT2A | |
| SCHEMBL5162024 | 0.82 | ABCB1 (0.47) | MEN1KMT2AABCB1 | |
| SCHEMBL5162369 | 0.82 | ABCB1 (0.47) | MEN1KMT2AABCB1 | |
| SCHEMBL5176974 | 0.82 | ABCB1 (0.47) | MEN1KMT2AABCB1 | |
| SCHEMBL14446241 | 0.81 | POLB (0.39) | POLBMEN1TSHRHTTKMT2A | |
| SCHEMBL14446248 | 0.78 | POLB (0.49) | POLBMEN1TSHRHTTKMT2A | |
| SCHEMBL5161731 | 0.76 | KDM1A (0.33) | POLBMEN1TSHRHTTKMT2A | |
| SCHEMBL5163160 | 0.76 | HTR2C (0.34) | POLBMEN1TSHRHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241798-B2 | NK1 antagonists | PFIZER INC. (US) | 2007-07-10 | — | — | US | disclosed |