Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 4/20 | 0.60 |
| ▸ | UBA3 | Q8TBC4 | 3/20 | 0.60 |
| ▸ | CA2 | P00918 | 2/20 | 0.60 |
| ▸ | UBA6 | A0AVT1 | 2/20 | 0.60 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.60 |
| ▸ | GRK5 | P34947 | 1/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.60 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.60 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ATG7 | O95352 | 1/20 | 0.42 |
| ▸ | UBA7 | P41226 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21637843 | 1.00 | NAE1 (0.60) | NAE1UBA3CA2UBA6SAE1 | |
| SCHEMBL192720 | 0.90 | NAE1 (0.59) | NAE1UBA3CA2UBA6SAE1 | |
| SCHEMBL193488 | 0.88 | NAE1 (0.72) | NAE1UBA3CA2UBA6SAE1 | |
| SCHEMBL193487 | 0.88 | NAE1 (0.72) | NAE1UBA3CA2UBA6SAE1 | |
| SCHEMBL193489 | 0.88 | NAE1 (0.72) | NAE1UBA3CA2UBA6SAE1 | |
| SCHEMBL17875199 | 0.86 | NAE1 (0.63) | NAE1UBA3CA2UBA6SAE1 | |
| SCHEMBL17866015 | 0.86 | NAE1 (0.58) | NAE1UBA3CA2UBA6SAE1 | |
| SCHEMBL17875185 | 0.86 | NAE1 (0.63) | NAE1UBA3CA2UBA6SAE1 | |
| SCHEMBL22400280 | 0.85 | NAE1 (0.61) | NAE1UBA3CA2UBA6SAE1 | |
| SCHEMBL17866022 | 0.84 | NAE1 (0.67) | NAE1UBA3CA2UBA6SAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007092213-A2 | INHIBITORS OF E1 ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-08-16 | — | — | WO | disclosed |