Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | RORA | P35398 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | RORB | Q92753 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13317079 | 0.85 | POLB (0.48) | ALDH1A1PLK1ADORA1KDM4EHPGD | |
| SCHEMBL13317113 | 0.84 | ADORA1 (0.46) | ALDH1A1ADORA2AADORA1KDM4EHPGD | |
| SCHEMBL13317101 | 0.84 | ADORA1 (0.46) | ALDH1A1ADORA1KDM4ELMNATP53 | |
| SCHEMBL13317087 | 0.82 | KDM4E (0.47) | ALDH1A1SMN1; SMN2PLK1APOBEC3GADORA1 | |
| SCHEMBL13317100 | 0.82 | TOP2A (0.47) | ALDH1A1CYP1A2ADORA1KDM4EHPGD | |
| SCHEMBL13317103 | 0.81 | POLB (0.45) | ALDH1A1SMN1; SMN2PLK1CYP1A2CYP2C19 | |
| SCHEMBL11825502 | 0.81 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2PLK1APOBEC3GTLR8 | |
| SCHEMBL11827984 | 0.80 | TDP1 (0.53) | ALDH1A1SMN1; SMN2PLK1APOBEC3GTLR8 | |
| SCHEMBL11821502 | 0.80 | TDP1 (0.53) | ALDH1A1SMN1; SMN2PLK1APOBEC3GTLR8 | |
| SCHEMBL13317102 | 0.80 | NPSR1 (0.44) | ALDH1A1SMN1; SMN2NPSR1ADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451196-B1 | The use of substituted tetracyclic imidazole derivatives as anti-histaminics | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-15 | — | — | EP | disclosed |