Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.95 |
| ▸ | CXCR1 | P25024 | 8/20 | 0.95 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.51 |
| ▸ | CCR4 | P51679 | 1/20 | 0.51 |
| ▸ | CCR6 | P51684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12263104 | 1.00 | CXCR2 (0.95) | CXCR2CXCR1CXCR3CCR4CCR6 | |
| SCHEMBL12263047 | 0.97 | CXCR2 (1.00) | CXCR2CXCR1CXCR3CCR4CCR6 | |
| SCHEMBL13590831 | 0.97 | CXCR2 (1.00) | CXCR2CXCR1CXCR3CCR4CCR6 | |
| SCHEMBL13479557 | 0.92 | CXCR2 (0.90) | CXCR2CXCR1CXCR3CCR6 | |
| SCHEMBL12263120 | 0.90 | CXCR2 (0.77) | CXCR2CXCR1 | |
| SCHEMBL12263097 | 0.89 | CXCR2 (0.76) | CXCR2CXCR1 | |
| SCHEMBL12262987 | 0.87 | CXCR2 (0.81) | CXCR2CXCR1 | |
| SCHEMBL12310899 | 0.87 | CXCR2 (0.81) | CXCR2CXCR1 | |
| SCHEMBL12263111 | 0.86 | CXCR2 (0.77) | CXCR2CXCR1 | |
| SCHEMBL12086782 | 0.86 | CXCR2 (1.00) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1818325-A2 | 3,4-DI-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands | SCHERING CORPORATION (US) | 2007-08-15 | — | — | EP | disclosed |