Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MTTP | P55157 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13839816 | 0.87 | GAA (0.52) | GAAPOLBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL13839812 | 0.85 | GAA (0.57) | GAAPOLBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL13839820 | 0.83 | GAA (0.50) | GAAPOLBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL13839824 | 0.83 | NPY2R (0.56) | GAAPOLBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL13839827 | 0.82 | MTTP (0.59) | GAAPOLBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL13839817 | 0.81 | SMN1; SMN2 (0.55) | GAAPOLBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL13839786 | 0.79 | MTTP (0.56) | MTTP | |
| SCHEMBL13839813 | 0.79 | GAA (0.55) | GAAPOLBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL13839821 | 0.78 | GAA (0.48) | GAAPOLBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL13839780 | 0.77 | MTTP (0.55) | MTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244848-B2 | Biphenylcarboxamides useful as lipid lowering agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-17 | — | — | US | disclosed |
| US-7244848-B2 | Biphenylcarboxamides useful as lipid lowering agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-17 | — | — | US | disclosed |