Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5514051 | 1.00 | KDM4E (0.42) | KDM4EALDH1A1TEAD1TEAD3HTR7 | |
| SCHEMBL5518005 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1 | |
| SCHEMBL5518000 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1 | |
| SCHEMBL5527711 | 0.79 | NPC1L1 (0.47) | TEAD1TEAD3 | |
| SCHEMBL5527710 | 0.79 | NPC1L1 (0.47) | TEAD1TEAD3 | |
| SCHEMBL5523265 | 0.78 | HIF1A (0.44) | TEAD1TEAD3 | |
| SCHEMBL5523261 | 0.78 | HIF1A (0.44) | TEAD1TEAD3 | |
| SCHEMBL5525148 | 0.78 | HIF1A (0.44) | TEAD1TEAD3HTR7 | |
| SCHEMBL5525155 | 0.78 | HIF1A (0.44) | TEAD1TEAD3HTR7 | |
| SCHEMBL5532506 | 0.77 | NPC1 (0.44) | TEAD1TEAD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167452-A1 | Therapeutic amide derivatives | PFIZER, INC. | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167452-A1 | Therapeutic amide derivatives | GRIN1, GRIN2B, GRIN3A | KDM4E 2535/4885ALDH1A1 1187/4885TEAD1 4001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.