Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 20/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 14/20 | 0.40 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14452428 | 0.91 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL14366744 | 0.90 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL4566497 | 0.88 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL5606076 | 0.88 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL4430117 | 0.87 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL14366747 | 0.84 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL5606374 | 0.83 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL14366746 | 0.83 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL14366751 | 0.83 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL14392651 | 0.79 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1TRAP1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007092496-A2 | 7,9-DIHYDRO-PURIN-8-ONE AND RELATED ANALOGS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-08-16 | — | — | WO | disclosed |