Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5738887 | 0.93 | KDR (0.46) | KDRMAPK14EGFRMAP2K1 | |
| SCHEMBL14451959 | 0.85 | KDR (0.48) | KDRMAPK14EGFRMAP2K1PIK3CA | |
| SCHEMBL4046080 | 0.84 | KDR (0.64) | KDRMAPK14EGFRMAP2K1 | |
| SCHEMBL14451949 | 0.83 | KDR (0.41) | KDRMAPK14EGFRMAP2K1 | |
| SCHEMBL14451966 | 0.81 | MAP2K1 (0.52) | KDRMAPK14EGFRMAP2K1 | |
| SCHEMBL14451967 | 0.80 | KDR (0.53) | KDRMAPK14EGFRMAP2K1 | |
| SCHEMBL14451958 | 0.79 | MAP2K1 (0.67) | KDRMAPK14EGFRMAP2K1 | |
| SCHEMBL14451943 | 0.79 | KDR (0.61) | KDRMAPK14EGFRMAP2K1 | |
| SCHEMBL5739638 | 0.79 | KDR (0.48) | KDRMAPK14EGFRMAP2K1 | |
| SCHEMBL14451954 | 0.78 | KDR (0.48) | KDRMAPK14EGFRMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244733-B2 | Pyrrolotriazine inhibitors of kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |