⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229791 | 0.77 | — | — | |
| SCHEMBL7747832 | 0.76 | — | — | |
| SCHEMBL13913082 | 0.76 | CA1 (0.33) | — | |
| SCHEMBL18709723 | 0.74 | — | — | |
| SCHEMBL3760967 | 0.73 | — | — | |
| SCHEMBL18869862 | 0.72 | CHRM2 (0.50) | — | |
| Sulfuric Acid SCHEMBL11750077 | 0.68 | KDM4E (0.38) | — | |
| SCHEMBL18869866 | 0.67 | CHRM2 (0.46) | — | |
| SCHEMBL13608823 | 0.67 | CHRM2 (0.46) | — | |
| SCHEMBL20046998 | 0.67 | MAOB (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215733-B1 | PYRIDYLOXYPHENOXYPROPIONIC ACID DERIVATIVES | SANDOZ AG (CH) | 1989-06-21 | — | — | EP | claimed |
| EP-1699760-B1 | ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2017-05-17 | — | — | EP | disclosed |
| EP-1699760-B1 | ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2017-05-17 | — | — | EP | disclosed |
| US-7999090-B2 | reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered; antifungal agents; inhibiting expression of cell wall glycoproteins and preventing pathogens from showing pathogenicity; DNA | EISAI CO., LTD (JP) | 2011-08-16 | — | — | US | disclosed |
| US-7999090-B2 | reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered; antifungal agents; inhibiting expression of cell wall glycoproteins and preventing pathogens from showing pathogenicity; DNA | EISAI CO., LTD (JP) | 2011-08-16 | — | — | US | disclosed |
| US-7999090-B2 | reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered; antifungal agents; inhibiting expression of cell wall glycoproteins and preventing pathogens from showing pathogenicity; DNA | EISAI CO., LTD (JP) | 2011-08-16 | — | — | US | disclosed |
| US-7928209-B2 | reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered; antifungal agents; inhibiting expression of cell wall glycoproteins and preventing pathogens from showing pathogenicity; DNA | EISAI R & D MANAGEMENT CO. LTD. (JP) | 2011-04-19 | — | — | US | disclosed |
| US-7928209-B2 | reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered; antifungal agents; inhibiting expression of cell wall glycoproteins and preventing pathogens from showing pathogenicity; DNA | EISAI R & D MANAGEMENT CO. LTD. (JP) | 2011-04-19 | — | — | US | disclosed |
| US-7928209-B2 | reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered; antifungal agents; inhibiting expression of cell wall glycoproteins and preventing pathogens from showing pathogenicity; DNA | EISAI R & D MANAGEMENT CO. LTD. (JP) | 2011-04-19 | — | — | US | disclosed |
| US-7910712-B2 | Fungal cell wall synthesis gene | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-03-22 | — | — | US | disclosed |
| US-20070078098-A1 | Anti-hypercholesterolemic compounds | MERCK SHARP & DOHME CORP. | 2007-04-05 | — | — | US | disclosed |
| EP-1723414-A2 | NPC1L1 (NPC3) AND METHODS OF IDENTIFYING LIGANDS THEREOF | Merck & Co., Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| US-20060234283-A1 | Fungal cell wall synthesis gene | EISAI CO., LTD. (JP) | 2006-10-19 | — | — | US | disclosed |
| US-20060234349-A1 | Fungal cell wall synthesis gene | EISAI CO., LTD. (JP) | 2006-10-19 | — | — | US | disclosed |
| EP-1699760-A2 | ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS | Merck & Co., Inc. (US) | 2006-09-13 | — | — | EP | disclosed |
| US-20050267049-A1 | Anti-hypercholesterolemic compounds | MERCK SHARP & DOHME LLC | 2005-12-01 | — | — | US | disclosed |
| WO-2005069900-A2 | NPC1L1 (NPC3) AND METHODS OF IDENTIFYING LIGANDS THEREOF | MERCK & CO., INC. (US) | 2005-08-04 | — | — | WO | disclosed |
| WO-2005062824-A2 | ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS | MERCK & CO., INC. (US) | 2005-07-14 | — | — | WO | disclosed |
| US-20040038239-A1 | Fungal cell wall synthesis gene | EISAI CO., LTD. (JP) | 2004-02-26 | — | — | US | disclosed |
| EP-1300464-A1 | FUNGAL CELL WALL SYNTHESIS GENE | Eisai Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |