Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Esomeprazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A known ✓ | P20648 | 7/20 | 0.49 |
| ▸ | ATP4B known ✓ | P51164 | 7/20 | 0.49 |
| ▸ | BRS3 | P32247 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ATP1A1 | P05023 | 4/20 | 0.49 |
| ▸ | ATP1B1 | P05026 | 4/20 | 0.49 |
| ▸ | ATP1A3 | P13637 | 4/20 | 0.49 |
| ▸ | ATP1B2 | P14415 | 4/20 | 0.49 |
| ▸ | ATP1A2 | P50993 | 4/20 | 0.49 |
| ▸ | ATP1B3 | P54709 | 4/20 | 0.49 |
| ▸ | FXYD2 | P54710 | 4/20 | 0.49 |
| ▸ | ATP1A4 | Q13733 | 4/20 | 0.49 |
| ▸ | WDR5 | P61964 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.49 |
| ▸ | ENGASE | Q8NFI3 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Esomeprazole SCHEMBL28300201 | 1.00 | BRS3 (0.51) | BRS3ATP4AATP4BKMT2AATP1A1 | |
| Omeprazole SCHEMBL589807 | 1.00 | BRS3 (0.51) | BRS3ATP4AATP4BKMT2AATP1A1 | |
| Omeprazole SCHEMBL665194 | 1.00 | BRS3 (0.51) | BRS3ATP4AATP4BKMT2AATP1A1 | |
| Esomeprazole SCHEMBL2484203 | 0.99 | BRS3 (0.50) | BRS3ATP4AATP4BKMT2AATP1A1 | |
| Omeprazole SCHEMBL1713666 | 0.99 | BRS3 (0.50) | BRS3ATP4AATP4BKMT2AATP1A1 | |
| Omeprazole SCHEMBL6829013 | 0.99 | BRS3 (0.50) | BRS3ATP4AATP4BKMT2AATP1A1 | |
| Omeprazole SCHEMBL4371701 | 0.99 | BRS3 (0.50) | BRS3ATP4AATP4BKMT2AATP1A1 | |
| Esomeprazole SCHEMBL142905 | 0.99 | BRS3 (0.50) | BRS3ATP4AATP4BKMT2AATP1A1 | |
| Esomeprazole SCHEMBL29002845 | 0.99 | BRS3 (0.50) | BRS3ATP4AATP4BKMT2AATP1A1 | |
| Omeprazole SCHEMBL28754295 | 0.99 | BRS3 (0.50) | BRS3ATP4AATP4BKMT2AATP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2173 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122056845-A | Esomeprazole enteric capsule, and preparation method and application thereof | 通化万通药业股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-20250241824-A1 | CHILD-PROOF STICK PACK | BAYER HEALTHCARE LLC | 2025-07-31 | — | — | US | claimed |
| CN-119925288-A | Preparation method of esomeprazole magnesium sodium bicarbonate capsule | 长春海悦药业股份有限公司 | 2025-05-06 | — | — | CN | claimed |
| CN-119909033-A | Esomeprazole magnesium enteric-coated particles and preparation method thereof | 江苏海之宏生物医药有限公司 | 2025-05-02 | — | — | CN | claimed |
| US-20250115575-A1 | A METHOD FOR PREPARING ESOMEPRAZOLE MAGNESIUM TRIHYDRATE BY CRYSTAL TRANSFORMATION | SHANDONG ANALYSIS AND TEST CENTER (CN) | 2025-04-10 | — | — | US | claimed |
| CN-119700689-A | Pharmaceutical composition containing esomeprazole magnesium and mosapride citrate and preparation method thereof | 浙江京新药业股份有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-118798828-B | Processing early warning system based on Esomeprazole magnesium enteric capsule pellets | 山东益健药业有限公司 | 2025-02-18 | — | — | CN | claimed |
| EP-4496754-A1 | CHILD-PROOF STICK PACK | Bayer Healthcare LLC (US) | 2025-01-29 | — | — | EP | claimed |
| CN-118649150-B | Preparation method of esomeprazole magnesium enteric capsule | 寿光富康制药有限公司 | 2024-12-20 | — | — | CN | claimed |
| CN-118946505-A | Child resistant stick pack | 拜耳医药保健有限责任公司 | 2024-11-12 | — | — | CN | claimed |
| WO-2004089274-A1 | DRUG PACKAGING, OR KIT, OR PRESENTATION FACILITATING SELF ADMINISTRATION OF DRUGS BY PATIENTS | MEDLEY S.A. INDÚSTRIA FARMACÊUTICA (BR) | 2004-10-21 | — | — | WO | claimed |
| WO-2004089414-A2 | COMBINATIONS OF PROTON PUMP INHIBITORS OR BLOCKERS WITH PROKINETIC AGENTS | MEDLEY S.A. INDÚSTRIA FARMACÊUTICA (BR) | 2004-10-21 | — | — | WO | claimed |
| US-20040167173-A1 | Amorphous hydrates of esomeprazole magnesium and process for the preparation thereof | DR. REDDY'S LABORATORIES LIMITED | 2004-08-26 | — | — | US | claimed |
| WO-2004046134-A2 | CRYSTALLINE FORM II OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE AND PROCESS FOR ITS PREPARATION | DR. REDDY'S LABORATORIES LIMITED (IN) | 2004-06-03 | — | — | WO | claimed |
| WO-2004045612-A1 | USE OF A PROTON PUMP INHIBITOR FOR PREVENTING POSTOPERATIVE NAUSEA AND VOMITING | ASTRAZENECA AB (SE) | 2004-06-03 | — | — | WO | claimed |
| WO-2004034973-A2 | METHOD OF TREATING SNORING AND OTHER OBSTRUCTIVE BREATHING DISORDERS | STERN WARREN (US) | 2004-04-29 | — | — | WO | claimed |
| WO-2004020436-A1 | AMORPHOUS HYDRATES OF ESOMEPRAZOLE MAGNESIUM AND PROCESS FOR THE PREPARATION THEREOF | REDDY'S LABORATORIES LIMITED (IN) | 2004-03-11 | — | — | WO | claimed |
| WO-2003082282-A1 | METHOD OF USE | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | claimed |
| EP-0813424-B1 | ORAL PHARMACEUTICAL DOSAGE FORMS COMPRISING A PROTON PUMP INHIBITOR AND AN ANTACID AGENT OR ALGINATE | ASTRAZENECA AB (SE) | 2002-11-20 | — | — | EP | claimed |
| EP-0754061-B1 | NEW ORAL PHARMACEUTICAL DOSAGE FORM | ASTRAZENECA AB (SE) | 2002-06-19 | — | — | EP | claimed |