SCHEMBL144590

SCHEMBL144590

Clc1nccc2ccccc12

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.70
CYP3A4 P08684 3/20 0.70
LMNA P02545 2/20 0.70
APEX1 P27695 1/20 0.70
MAPK1 P28482 1/20 0.70
PMP22 Q01453 1/20 0.70
CYP2A6 P11509 4/20 0.56
PLAU P00749 2/20 0.56
F12 P00748 1/20 0.56
NCF1 P14598 1/20 0.56
NOS3 P29474 1/20 0.56
NOS1 P29475 1/20 0.56
NOS2 P35228 1/20 0.56
BACE1 P56817 1/20 0.56
CYP1A2 P05177 1/20 0.46
PLG P00747 1/20 0.46
PDE4A P27815 1/20 0.45
PDE4B Q07343 1/20 0.45
PDE4C Q08493 1/20 0.45
PDE4D Q08499 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29536823 1.00 MAPT (0.70) MAPTCYP3A4LMNAAPEX1MAPK1
Hydrochloric Acid SCHEMBL11811816 0.98 MAPT (0.68) MAPTCYP3A4LMNAAPEX1MAPK1
SCHEMBL6066322 0.84 CYP3A4 (0.62) MAPTCYP3A4LMNAAPEX1MAPK1
SCHEMBL29378651 0.83 CYP3A4 (1.00) MAPTCYP3A4LMNAAPEX1MAPK1
SCHEMBL29836842 0.83 CYP3A4 (0.61) MAPTCYP3A4LMNAAPEX1MAPK1
SCHEMBL31495222 0.83 CYP3A4 (1.00) MAPTCYP3A4LMNAAPEX1MAPK1
SCHEMBL28838096 0.83 CYP3A4 (0.61) MAPTCYP3A4LMNAAPEX1MAPK1
SCHEMBL30634955 0.83 CYP3A4 (1.00) MAPTCYP3A4LMNAAPEX1MAPK1
SCHEMBL610880 0.83 CYP3A4 (1.00) MAPTCYP3A4LMNAAPEX1MAPK1
SCHEMBL15911815 0.83 CYP3A4 (1.00) MAPTCYP3A4LMNAAPEX1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2117 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117865932-B Preparation method of benzothiophene sulfone compound with medicinal and fluorescent activity BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY (CN) 2026-05-26 CN claimed
CN-119285543-B Sulfonylation method of halogenated quinoline and aryl sulfonyl hydrazine 南京工业大学 2026-05-15 CN claimed
CN-116903678-B Iridium complex-nitroimidazole conjugate and preparation method and application thereof 东北师范大学 2025-06-24 CN claimed
CN-120005095-A Platinum metal polymer high molecular material, preparation method and application thereof 榆林学院 2025-05-16 CN claimed
CN-119841818-A Carbazole derivative and preparation method and application thereof 福建理工大学 2025-04-18 CN claimed
CN-119708077-A PH response type organic fluorescent probe and preparation method and application thereof 江苏可立特工程设计研究有限公司 2025-03-28 CN claimed
CN-119320413-A Ionic iridium complex photosensitizer as well as preparation method and application thereof 南京工业大学 2025-01-17 CN claimed
CN-119285543-A Sulfonylation method of halogenated quinoline and aryl sulfonyl hydrazine 南京工业大学 2025-01-10 CN claimed
CN-119119130-A Metal iridium complex with porphyrin moiety for multi-mode thrombolysis, preparation method, nano particle and application 深圳市第二人民医院(深圳市转化医学研究院) 2024-12-13 CN claimed
CN-119039356-A Fluoranthene group-containing deep red to near infrared iridium (III) complex, preparation method and application thereof 西安交通大学 2024-11-29 CN claimed
CN-104628783-A Organic iridium metal complex as well as preparation method and application thereof OCEANS KING LIGHTING SCIENCE 2015-05-20 CN claimed
CN-104628641-A Organic iridium metal complex as well as preparation method and application thereof OCEANS KING LIGHTING SCIENCE 2015-05-20 CN claimed
CN-104629749-A Organic electrophosphorescence material, as well as preparation method and organic electroluminescent device thereof OCEANS KING LIGHTING SCIENCE 2015-05-20 CN claimed
CN-101573354-B Substituted isoquinolines and their use as Rho-kinase inhibitors SANOFI AVENTIS SPA 2014-02-12 CN claimed
CN-103382216-A Cyanoisoquinoline compounds and methods of use thereof FIBROGEN INC 2013-11-06 CN claimed
CN-101285061-A Fungal cell wall synthetic genes EISAI R&D MAN CO LTD (JP) 2008-10-15 CN claimed
CN-1283638-C Indole-2-formamide compounds as factor Xa inhibitors AVENTIS PHARMA GMBH (DE) 2006-11-08 CN claimed
CN-1249227-C Fungal cell wall synthetic genes EISAI CO LTD (JP) 2006-04-05 CN claimed
CN-1449443-A Fungal cell wall synthetic genes EISAI CO LTD (JP) 2003-10-15 CN claimed
EP-0187371-B1 SUBSTITUTED ISOQUINOLINESULFONYL COMPOUNDS Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1991-06-19 EP claimed