Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 16/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | TXK | P42681 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14460463 | 0.86 | ITK (0.69) | ITKNTRK1CDK2BTK | |
| SCHEMBL14460626 | 0.84 | ITK (0.80) | ITK | |
| SCHEMBL5656418 | 0.83 | NTRK1 (0.46) | ITKNTRK1CDK2 | |
| SCHEMBL5658013 | 0.80 | ITK (1.00) | ITK | |
| SCHEMBL14461030 | 0.79 | ITK (0.79) | ITKNTRK1CDK2 | |
| SCHEMBL14460989 | 0.79 | ITK (1.00) | ITKNTRK1CDK2JAK3BTK | |
| SCHEMBL14461032 | 0.78 | ITK (0.77) | ITKNTRK1CDK2 | |
| SCHEMBL14461031 | 0.78 | ITK (1.00) | ITKNTRK1CDK2 | |
| SCHEMBL14461038 | 0.78 | ITK (0.73) | ITKNTRK1CDK2 | |
| SCHEMBL14461000 | 0.77 | ITK (0.83) | ITKNTRK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241781-B2 | 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241781-B2 | 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |