Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 19/20 | 0.71 |
| ▸ | ITK | Q08881 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14460925 | 0.88 | NTRK1 (0.73) | NTRK1ITKCDK2 | |
| SCHEMBL14460934 | 0.88 | NTRK1 (0.74) | NTRK1ITK | |
| SCHEMBL14460935 | 0.86 | NTRK1 (0.72) | NTRK1ITK | |
| SCHEMBL14460958 | 0.82 | NTRK1 (0.73) | NTRK1ITK | |
| SCHEMBL5662543 | 0.82 | NTRK1 (1.00) | NTRK1ITK | |
| SCHEMBL14460952 | 0.82 | NTRK1 (0.78) | NTRK1ITKCDK2 | |
| SCHEMBL14460886 | 0.82 | NTRK1 (0.81) | NTRK1ITKCDK2 | |
| SCHEMBL14460960 | 0.82 | NTRK1 (0.67) | NTRK1ITK | |
| SCHEMBL14460929 | 0.81 | NTRK1 (0.72) | NTRK1ITK | |
| SCHEMBL14460973 | 0.81 | NTRK1 (0.70) | NTRK1ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241781-B2 | 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241781-B2 | 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |