Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 18/20 | 0.88 |
| ▸ | ITK | Q08881 | 2/20 | 0.72 |
| ▸ | CDK2 | P24941 | 1/20 | 0.66 |
| ▸ | JAK3 | P52333 | 1/20 | 0.65 |
| ▸ | BTK | Q06187 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14460947 | 0.99 | NTRK1 (0.87) | NTRK1ITKCDK2JAK3BTK | |
| SCHEMBL5655992 | 0.93 | NTRK1 (1.00) | NTRK1ITKCDK2JAK3BTK | |
| SCHEMBL14460971 | 0.92 | NTRK1 (0.82) | NTRK1ITKCDK2JAK3BTK | |
| SCHEMBL5657610 | 0.91 | NTRK1 (0.84) | NTRK1ITKCDK2JAK3BTK | |
| SCHEMBL5659174 | 0.91 | NTRK1 (0.81) | NTRK1ITKCDK2JAK3BTK | |
| SCHEMBL5658598 | 0.91 | NTRK1 (0.84) | NTRK1ITKCDK2JAK3BTK | |
| SCHEMBL5655936 | 0.91 | NTRK1 (0.75) | NTRK1ITKCDK2JAK3BTK | |
| SCHEMBL14460915 | 0.90 | NTRK1 (0.75) | NTRK1ITKCDK2JAK3BTK | |
| SCHEMBL5657134 | 0.90 | NTRK1 (0.75) | NTRK1ITKCDK2JAK3BTK | |
| SCHEMBL14460962 | 0.89 | NTRK1 (0.79) | NTRK1ITKCDK2JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241781-B2 | 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241781-B2 | 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |