Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 18/20 | 0.70 |
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
| ▸ | ITK | Q08881 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14460982 | 0.90 | NTRK1 (0.79) | NTRK1CDK2ITK | |
| SCHEMBL14460901 | 0.86 | NTRK1 (0.68) | NTRK1CDK2ITK | |
| SCHEMBL14460984 | 0.86 | NTRK1 (0.75) | NTRK1CDK2ITK | |
| SCHEMBL14460940 | 0.86 | NTRK1 (0.79) | NTRK1CDK2ITK | |
| SCHEMBL14460943 | 0.84 | NTRK1 (0.73) | NTRK1CDK2ITK | |
| SCHEMBL14460986 | 0.84 | NTRK1 (0.72) | NTRK1CDK2ITK | |
| SCHEMBL5658369 | 0.83 | NTRK1 (0.83) | NTRK1CDK2ITK | |
| SCHEMBL14460924 | 0.82 | NTRK1 (0.67) | NTRK1CDK2ITK | |
| SCHEMBL14460918 | 0.82 | NTRK1 (0.70) | NTRK1CDK2ITK | |
| SCHEMBL14460886 | 0.82 | NTRK1 (0.81) | NTRK1CDK2ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241781-B2 | 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241781-B2 | 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |