Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.77 |
| ▸ | LCK | P06239 | 4/20 | 0.76 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.76 |
| ▸ | CSF1R | P07333 | 2/20 | 0.76 |
| ▸ | KDR | P35968 | 1/20 | 0.76 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14078303 | 0.92 | MAPK14 (0.86) | MAPK14LCKMAP2K1CSF1RKDR | |
| SCHEMBL6487595 | 0.87 | MAPK14 (1.00) | MAPK14LCKMAP2K1CSF1RKDR | |
| SCHEMBL5124614 | 0.86 | MAPK14 (1.00) | MAPK14LCKMAP2K1CSF1RKDR | |
| SCHEMBL14463260 | 0.84 | MAPK14 (0.85) | MAPK14LCKMAP2K1CSF1RKDR | |
| SCHEMBL14078304 | 0.81 | MAPK14 (0.71) | MAPK14LCKMAP2K1CSF1RKDR | |
| SCHEMBL6604303 | 0.80 | MAPK14 (0.68) | MAPK14LCKMAP2K1CSF1RKDR | |
| SCHEMBL6605456 | 0.79 | MAPK14 (0.69) | MAPK14LCKMAP2K1CSF1RKDR | |
| SCHEMBL5221091 | 0.78 | MAPK14 (0.64) | MAPK14LCKMAP2K1CSF1RKDR | |
| SCHEMBL4858353 | 0.78 | MAPK14 (1.00) | MAPK14LCKMAP2K1CSF1RKDR | |
| SCHEMBL14078286 | 0.77 | MAPK14 (0.77) | MAPK14LCKMAP2K1CSF1RKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499600-B1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | disclosed |