Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.56 |
| ▸ | PDE6D | O43924 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | PDE6A | P16499 | 1/20 | 0.53 |
| ▸ | PDE6G | P18545 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | PDE6B | P35913 | 1/20 | 0.53 |
| ▸ | PDE6C | P51160 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.53 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.53 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227105 | 1.00 | PDE5A (0.56) | PDE5APDE6DNR1I2PDE6APDE6G | |
| SCHEMBL14464011 | 0.86 | PDE5A (0.70) | PDE5APDE6DNR1I2PDE6APDE6G | |
| SCHEMBL5231420 | 0.86 | PDE5A (0.70) | PDE5APDE6DNR1I2PDE6APDE6G | |
| SCHEMBL14464006 | 0.86 | PDE5A (0.70) | PDE5APDE6DNR1I2PDE6APDE6G | |
| SCHEMBL14464010 | 0.86 | PDE5A (0.70) | PDE5APDE6DNR1I2PDE6APDE6G | |
| SCHEMBL14463497 | 0.86 | PDE5A (0.70) | PDE5APDE6DNR1I2PDE6APDE6G | |
| SCHEMBL1326404 | 0.83 | PDE5A (0.77) | PDE5APDE6DNR1I2PDE6APDE6G | |
| SCHEMBL1326406 | 0.83 | PDE5A (0.77) | PDE5APDE6DNR1I2PDE6APDE6G | |
| SCHEMBL7441972 | 0.83 | PDE5A (0.77) | PDE5APDE6DNR1I2PDE6APDE6G | |
| SCHEMBL1921236 | 0.83 | PDE5A (0.77) | PDE5APDE6DNR1I2PDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448562-B1 | SUBSTITUTED TETRACYCLIC PYRROLOQUINOLONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | ORTHO MCNEIL PHARMACEUTICAL CO (US) | 2007-07-25 | — | — | EP | disclosed |