Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.85 |
| ▸ | CACNA2D1 | P54289 | 8/20 | 0.70 |
| ▸ | CACNB1 | Q02641 | 8/20 | 0.70 |
| ▸ | CACNA1B | Q00975 | 7/20 | 0.70 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.70 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.70 |
| ▸ | HRH1 | P35367 | 3/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.69 |
| ▸ | HRH2 | P25021 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.69 |
| ▸ | DRD3 | P35462 | 1/20 | 0.69 |
| ▸ | HTR2B | P41595 | 1/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.69 |
| ▸ | TEK | Q02763 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.68 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1446803 | 1.00 | NPC1 (0.85) | NPC1CACNA2D1CACNB1CACNA1BCACNA1G | |
| SCHEMBL7665618 | 0.96 | NPC1 (0.78) | NPC1CACNA2D1CACNB1CACNA1BCACNA1G | |
| SCHEMBL1446717 | 0.92 | NPC1 (0.71) | NPC1CACNA2D1CACNB1CACNA1BCACNA1G | |
| SCHEMBL15703692 | 0.92 | NPC1 (0.71) | NPC1CACNA2D1CACNB1CACNA1BCACNA1G | |
| SCHEMBL13574307 | 0.87 | CACNA2D1 (0.65) | NPC1CACNA2D1CACNB1CACNA1BCACNA1G | |
| SCHEMBL15703563 | 0.87 | CACNA2D1 (0.65) | NPC1CACNA2D1CACNB1CACNA1BCACNA1G | |
| SCHEMBL15703562 | 0.87 | CACNA2D1 (0.65) | NPC1CACNA2D1CACNB1CACNA1BCACNA1G | |
| SCHEMBL18326949 | 0.86 | HRH1 (0.81) | NPC1CACNA2D1CACNB1CACNA1BCACNA1G | |
| SCHEMBL15703530 | 0.86 | NPC1 (0.63) | NPC1CACNA2D1CACNB1CACNA1BCACNA1G | |
| SCHEMBL15703531 | 0.86 | NPC1 (0.63) | NPC1CACNA2D1CACNB1CACNA1BCACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297122-B1 | NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF | KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) | 2014-05-21 | — | — | EP | disclosed |
| EP-2297122-B1 | NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF | KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) | 2014-05-21 | — | — | EP | disclosed |
| EP-2297122-A1 | NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF | KRKA, tovarna zdravil, d.d., Novo mesto (SI) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009150147-A1 | NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009150147-A1 | NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2009-12-17 | — | — | WO | disclosed |