Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.58 |
| ▸ | PDE4A | P27815 | 10/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.54 |
| ▸ | EEF2K | O00418 | 2/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898463 | 0.87 | BRAF (0.74) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281589 | 0.81 | BRAF (0.63) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4904031 | 0.80 | BRAF (0.72) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4904040 | 0.73 | BRAF (0.84) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4909324 | 0.73 | BRAF (1.00) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4902994 | 0.73 | BRAF (1.00) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281412 | 0.71 | BRAF (0.81) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4906905 | 0.71 | BRAF (0.79) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4898188 | 0.71 | BRAF (0.79) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14306527 | 0.71 | BRAF (0.79) | BRAFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084560-A2 | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |