Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.70 |
| ▸ | PDE4A | P27815 | 13/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 2/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | PRKACG | P22612 | 1/20 | 0.49 |
| ▸ | PRKACB | P22694 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4899393 | 0.91 | BRAF (0.58) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281346 | 0.83 | BRAF (0.78) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4923252 | 0.83 | BRAF (1.00) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4918120 | 0.82 | BRAF (0.75) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4906962 | 0.81 | BRAF (0.68) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4924409 | 0.81 | BRAF (0.70) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4899466 | 0.81 | BRAF (0.70) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14466584 | 0.80 | BRAF (0.66) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4903856 | 0.78 | BRAF (1.00) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4904094 | 0.78 | BRAF (0.85) | BRAFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084560-A2 | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |