Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 5/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14447551 | 0.95 | TLR8 (0.54) | KDM4EADORA2AEHMT2ITKCNR2 | |
| SCHEMBL19436514 | 0.86 | KDM4E (0.56) | KDM4EADORA2AEHMT2ITKBACE1 | |
| Bromide SCHEMBL23227960 | 0.85 | KDM4E (0.55) | KDM4EADORA2AEHMT2ITKBACE1 | |
| SCHEMBL2362229 | 0.83 | KDM4E (0.58) | KDM4EADORA2AEHMT2ITKCNR2 | |
| SCHEMBL21437365 | 0.82 | EHMT2 (0.71) | KDM4EADORA2AEHMT2ITKBACE1 | |
| SCHEMBL19451670 | 0.80 | KMT2A (0.55) | — | |
| SCHEMBL22121391 | 0.80 | KDM4E (0.60) | KDM4EADORA2AEHMT2ITKCNR2 | |
| SCHEMBL21310941 | 0.78 | TLR7 (0.58) | KDM4EADORA2AEHMT2ITKCNR2 | |
| SCHEMBL30897550 | 0.78 | KDM4E (0.56) | KDM4EEHMT2ITKCNR2PTGER4 | |
| SCHEMBL11947887 | 0.78 | KDM4E (0.56) | KDM4EEHMT2ITKCNR2PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244847-B2 | Benzimidazole compounds | ISIS PHARMACEUTICALS, INC. (US) | 2007-07-17 | — | — | US | disclosed |