Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14622872 | 0.92 | CYP3A4 (0.48) | CYP3A4 | |
| SCHEMBL13591134 | 0.91 | CYP3A4 (0.51) | CYP3A4KDM4EALDH1A1MAPTHTT | |
| SCHEMBL13591102 | 0.89 | CYP3A4 (0.49) | CYP3A4KDM4EALDH1A1MAPTHTT | |
| SCHEMBL13591179 | 0.89 | CYP3A4 (0.51) | CYP3A4KDM4EALDH1A1MAPTHTT | |
| SCHEMBL13591101 | 0.87 | CYP3A4 (0.47) | CYP3A4KCNH2HRH3 | |
| SCHEMBL14091058 | 0.87 | CYP3A4 (0.51) | CYP3A4 | |
| SCHEMBL13591236 | 0.86 | CYP3A4 (0.47) | CYP3A4KCNH2HRH3 | |
| SCHEMBL14091054 | 0.86 | CYP3A4 (0.46) | CYP3A4KCNH2HRH3 | |
| SCHEMBL13591253 | 0.86 | CYP3A4 (0.48) | CYP3A4KDM4EALDH1A1MAPTHTT | |
| SCHEMBL13591113 | 0.85 | CYP3A4 (0.52) | CYP3A4KDM4EALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070010513-A1 | Carbon-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists | SCHERING CORPORATION | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010513-A1 | Carbon-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists | HRH3, HRH4, CHRM1 | CYP3A4 907/4885KCNH2 1376/4885HRH3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.