Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14090976 | 0.91 | HRH3 (0.59) | HRH3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14090970 | 0.84 | HRH3 (0.64) | HRH3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14622491 | 0.79 | HRH3 (0.59) | HRH3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13591130 | 0.79 | HRH3 (0.59) | HRH3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8225753 | 0.79 | HRH3 (0.65) | HRH3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14090981 | 0.78 | HRH3 (0.63) | HRH3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14622033 | 0.77 | HRH3 (0.57) | HRH3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13591245 | 0.77 | HRH3 (0.65) | HRH3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14090956 | 0.77 | HRH3 (0.64) | HRH3CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14090948 | 0.77 | HRH3 (0.64) | HRH3CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |