SCHEMBL14469784

SCHEMBL14469784

C=C(C)c1cccc(C2(NC[C@@H](O)C(Cc3cc(F)cc(F)c3)NC(C)=O)CC2)c1

nearest known ligand 0.91

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 20/20 0.91
CTSD P07339 10/20 0.84
CYP3A4 P08684 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3177811 1.00 BACE1 (0.91) BACE1CTSDCYP3A4
SCHEMBL13349440 1.00 BACE1 (0.91) BACE1CTSDCYP3A4
SCHEMBL3177801 1.00 BACE1 (0.91) BACE1CTSDCYP3A4
SCHEMBL5666447 0.95 BACE1 (1.00) BACE1CTSD
SCHEMBL4697921 0.91 BACE1 (1.00) BACE1CTSDCYP3A4
SCHEMBL5666960 0.88 BACE1 (0.87) BACE1CTSD
SCHEMBL13349523 0.88 BACE1 (0.78) BACE1CTSDCYP3A4
SCHEMBL6041078 0.87 BACE1 (0.85) BACE1CTSD
SCHEMBL3167544 0.87 BACE1 (0.77) BACE1CTSDCYP3A4
SCHEMBL4700493 0.87 BACE1 (0.77) BACE1CTSDCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7244725-B2 Acetyl 2-hydroxy-1, 3-diaminoalkanes ELAN PHARMACEUTICALS, INC. (US) 2007-07-17 US disclosed