Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.69 |
| ▸ | CDK1 | P06493 | 5/20 | 0.60 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCNH | P51946 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447113 | 0.90 | CDK2 (0.74) | CDK2CDK1CDK4KCNH2 | |
| SCHEMBL1447567 | 0.90 | CDK2 (0.72) | CDK2CDK1BTKCDK4JAK2 | |
| SCHEMBL1447392 | 0.85 | CDK2 (0.82) | CDK2CDK1CDK4KCNH2CCNT1 | |
| SCHEMBL1447630 | 0.84 | CDK2 (0.69) | CDK2CDK1BTKJAK2LRRK2 | |
| SCHEMBL1447718 | 0.82 | CDK2 (0.77) | CDK2CDK1CDK4KCNH2CCNT1 | |
| SCHEMBL14021578 | 0.80 | JAK2 (0.64) | CDK2BTKJAK2LRRK2PLK4 | |
| SCHEMBL1448559 | 0.80 | CDK2 (0.73) | CDK2CDK1KCNH2 | |
| SCHEMBL1448311 | 0.80 | CDK2 (0.62) | CDK2CDK1CDK4KCNH2 | |
| SCHEMBL1447247 | 0.80 | CDK2 (0.65) | CDK2CDK1 | |
| SCHEMBL3939749 | 0.79 | CDK2 (0.69) | CDK2CDK1BTKLRRK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301928-A1 | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |