Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 2/20 | 0.32 |
| ▸ | PRKCB | P05771 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3566529 | 0.90 | MAPT (0.35) | MAPTALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL3566532 | 0.90 | MAPT (0.35) | MAPTALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL14472900 | 0.87 | EPHX2 (0.34) | EPHX2MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL3574927 | 0.79 | MCHR1 (0.37) | MAPT | |
| SCHEMBL3574925 | 0.79 | MCHR1 (0.37) | MAPT | |
| SCHEMBL3566004 | 0.78 | APP (0.34) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL3566002 | 0.78 | APP (0.34) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL3570580 | 0.77 | SYK (0.37) | MAPTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL3570584 | 0.77 | SYK (0.37) | MAPTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL3570243 | 0.77 | MAPT (0.35) | MAPTALDH1A1HPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075783-A2 | SUBSTITUTED ISOQUINOLINE-1,3(2H,4H)-DIONES, 1-THIOXO-1,4-DIHYDRO-2H-ISOQUINOLINE-3-ONES AND 1,4-DIHYDRO-3(2H)-ISOQUINOLONES AND USE THEREOF AS KINASE INHIBITOR | WYETH (US) | 2007-07-05 | — | — | WO | disclosed |