Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK2 | P53671 | 16/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 9/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | PRKACG | P22612 | 1/20 | 0.48 |
| ▸ | PRKACB | P22694 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4296922 | 0.92 | LIMK2 (0.46) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL1446502 | 0.78 | LIMK2 (0.54) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL1446740 | 0.76 | LIMK2 (0.59) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL1447058 | 0.76 | LIMK2 (0.51) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL1446658 | 0.74 | LIMK2 (0.46) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL1446726 | 0.74 | LIMK2 (0.46) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL1446917 | 0.70 | LIMK2 (0.48) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL1448863 | 0.70 | LIMK2 (0.51) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL1446947 | 0.70 | LIMK2 (0.44) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL4301992 | 0.70 | LIMK2 (0.84) | LIMK2LIMK1ROCK1ROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297153-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009131940-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |