Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 5/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 10/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 5/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16184686 | 0.91 | ABCB1 (0.41) | GBA1ABCB1ABCC1GMNNLMNA | |
| SCHEMBL14474167 | 0.84 | GBA1 (0.42) | GBA1ABCB1GMNNLMNACYP1A2 | |
| SCHEMBL16184520 | 0.83 | GBA1 (0.41) | GBA1ABCB1GMNNLMNACYP1A2 | |
| SCHEMBL16184678 | 0.83 | GBA1 (0.51) | GBA1LMNACYP1A2CYP3A4MAPT | |
| SCHEMBL16184658 | 0.83 | GBA1 (0.42) | GBA1ABCB1GMNNLMNACYP1A2 | |
| SCHEMBL16184675 | 0.82 | GBA1 (0.52) | GBA1ABCB1ABCC1 | |
| SCHEMBL16184633 | 0.81 | DYRK1A (0.40) | GBA1ABCB1GMNNLMNACYP1A2 | |
| SCHEMBL16184494 | 0.81 | GBA1 (0.42) | GBA1ABCB1GMNNLMNACYP1A2 | |
| SCHEMBL14474225 | 0.80 | GBA1 (0.38) | GBA1ABCB1ABCC1 | |
| SCHEMBL16184573 | 0.80 | DYRK1A (0.40) | GBA1ABCB1GMNNLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013003586-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-01-03 | — | — | WO | disclosed |