Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 5/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14474480 | 0.93 | GBA1 (0.52) | GBA1ABCG2ABCB1HPGDSMAPT | |
| SCHEMBL18022995 | 0.93 | GBA1 (0.52) | GBA1ABCG2ABCB1HPGDSMAPT | |
| SCHEMBL14475772 | 0.87 | ABCG2 (0.51) | GBA1ABCG2ABCB1MAPTMEN1 | |
| SCHEMBL14727281 | 0.79 | ABCG2 (0.52) | GBA1ABCG2ABCB1MAPTMEN1 | |
| SCHEMBL14474911 | 0.79 | ABCG2 (0.53) | GBA1ABCG2ABCB1MAPTMEN1 | |
| SCHEMBL14473996 | 0.79 | ABCG2 (0.53) | GBA1ABCG2ABCB1MAPTMEN1 | |
| SCHEMBL20273441 | 0.78 | ABCG2 (0.59) | ABCG2ABCB1MAPTMEN1KMT2A | |
| SCHEMBL14474935 | 0.78 | ABCG2 (0.52) | GBA1ABCG2ABCB1MAPTMEN1 | |
| SCHEMBL2155380 | 0.78 | ABCG2 (0.52) | GBA1ABCG2ABCB1MAPTMEN1 | |
| SCHEMBL14474138 | 0.78 | ABCG2 (0.60) | ABCG2ABCB1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013003586-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-01-03 | — | — | WO | disclosed |