Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.78 |
| ▸ | CDK1 | P06493 | 9/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | CDK4 | P11802 | 3/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447657 | 1.00 | CDK2 (0.78) | CDK2CDK1KCNH2CDK4CDK6 | |
| Hydrochloric Acid SCHEMBL4246263 | 0.88 | CDK2 (0.66) | CDK2CDK1KCNH2CDK4CDK6 | |
| SCHEMBL1447395 | 0.87 | CDK2 (1.00) | CDK2CDK1KCNH2 | |
| SCHEMBL1447982 | 0.87 | CDK2 (1.00) | CDK2CDK1KCNH2 | |
| SCHEMBL1448906 | 0.85 | CDK2 (0.65) | CDK2CDK1KCNH2CDK4CDK6 | |
| SCHEMBL1448567 | 0.85 | CDK2 (0.65) | CDK2CDK1KCNH2CDK4CDK6 | |
| SCHEMBL1447839 | 0.84 | CDK2 (0.67) | CDK2CDK1KCNH2CDK4CDK6 | |
| SCHEMBL3937001 | 0.84 | CDK2 (0.72) | CDK2CDK1KCNH2CDK6 | |
| Hydrochloric Acid SCHEMBL4247263 | 0.83 | CDK2 (0.71) | CDK2CDK1KCNH2CDK6 | |
| Hydrochloric Acid SCHEMBL4246172 | 0.82 | CDK2 (0.60) | CDK2CDK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301928-A1 | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |