Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | ACACB | O00763 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14478297 | 1.00 | SLC6A4 (0.61) | SLC6A4SCN10ATAAR1SLC6A2SLC6A3 | |
| SCHEMBL14944878 | 0.87 | SLC6A4 (0.59) | SLC6A4TAAR1SLC6A2SLC6A3 | |
| SCHEMBL14478249 | 0.86 | SLC6A4 (0.58) | SLC6A4TAAR1SLC6A2SLC6A3 | |
| SCHEMBL1912504 | 0.85 | ACACB (0.51) | SLC6A4SCN10ASLC6A2SLC6A3ACACB | |
| SCHEMBL22341178 | 0.84 | EPHX2 (0.66) | ACACBEPHX1 | |
| SCHEMBL19015929 | 0.83 | SLC6A4 (0.63) | SLC6A4TAAR1SLC6A2SLC6A3 | |
| SCHEMBL1416925 | 0.81 | ACACB (0.52) | SLC6A4ACACBEPHX1 | |
| SCHEMBL20821070 | 0.81 | ACACB (0.49) | SLC6A4SCN10ASLC6A2SLC6A3ACACB | |
| SCHEMBL25509116 | 0.81 | ACACB (0.49) | SLC6A4SCN10ASLC6A2SLC6A3ACACB | |
| SCHEMBL14478257 | 0.81 | TAAR1 (0.65) | SLC6A4TAAR1SLC6A2SLC6A3EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343928-B2 | Monomethylvaline compounds having phenylalanine side-chain replacements at the C-terminus | SEATTLE GENETICS, INC. (US) | 2013-01-01 | — | — | US | disclosed |