Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.63 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12313578 | 0.84 | SLC6A4 (0.68) | SLC6A4TAAR1SLC6A2SLC6A3MAOA | |
| SCHEMBL8226572 | 0.84 | ACACB (0.50) | SLC6A4 | |
| SCHEMBL28508358 | 0.79 | SLC6A4 (0.73) | SLC6A4TAAR1SLC6A2SLC6A3MAOA | |
| SCHEMBL10774940 | 0.79 | SLC6A4 (0.73) | SLC6A4TAAR1SLC6A2SLC6A3MAOA | |
| SCHEMBL317872 | 0.79 | ST14 (0.50) | SLC6A4 | |
| SCHEMBL20397876 | 0.79 | PCNA (0.44) | SLC6A4 | |
| SCHEMBL27986770 | 0.79 | SLC6A4 (0.61) | SLC6A4TAAR1SLC6A2SLC6A3MAOA | |
| SCHEMBL27987191 | 0.79 | SLC6A4 (0.61) | SLC6A4TAAR1SLC6A2SLC6A3MAOA | |
| SCHEMBL27986772 | 0.79 | SLC6A4 (0.61) | SLC6A4TAAR1SLC6A2SLC6A3MAOA | |
| SCHEMBL10872752 | 0.78 | TAAR1 (0.76) | SLC6A4TAAR1SLC6A2SLC6A3MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343928-B2 | Monomethylvaline compounds having phenylalanine side-chain replacements at the C-terminus | SEATTLE GENETICS, INC. (US) | 2013-01-01 | — | — | US | disclosed |