Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.73 |
| ▸ | CDK1 | P06493 | 7/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | IKBKB | O14920 | 3/20 | 0.48 |
| ▸ | CHUK | O15111 | 3/20 | 0.48 |
| ▸ | IKBKG | Q9Y6K9 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447563 | 0.98 | CDK2 (0.72) | CDK2CDK1KCNH2IKBKBCHUK | |
| SCHEMBL1447628 | 0.97 | CDK2 (0.69) | CDK2CDK1KCNH2IKBKBCHUK | |
| SCHEMBL3939749 | 0.92 | CDK2 (0.69) | CDK2CDK1KCNH2SYK | |
| SCHEMBL1447630 | 0.89 | CDK2 (0.69) | CDK2CDK1KCNH2IKBKBCHUK | |
| SCHEMBL1448597 | 0.88 | CDK2 (0.66) | CDK2CDK1KCNH2SYK | |
| SCHEMBL1447537 | 0.88 | CDK2 (0.61) | CDK2CDK1KCNH2SYK | |
| SCHEMBL1447839 | 0.85 | CDK2 (0.67) | CDK2CDK1KCNH2IKBKBCHUK | |
| SCHEMBL1447633 | 0.85 | CDK2 (0.59) | CDK2CDK1KCNH2SYK | |
| SCHEMBL1447265 | 0.84 | CDK2 (0.69) | CDK2CDK1KCNH2SYK | |
| SCHEMBL1447218 | 0.84 | CDK2 (0.84) | CDK2CDK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301928-A1 | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |