Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.78 |
| ▸ | CDK1 | P06493 | 8/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.69 |
| ▸ | IKBKB | O14920 | 1/20 | 0.59 |
| ▸ | CHUK | O15111 | 1/20 | 0.59 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.57 |
| ▸ | CCND1 | P24385 | 1/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.57 |
| ▸ | CCND3 | P30281 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447616 | 0.95 | CDK2 (0.83) | CDK2CDK1KCNH2CCNT1CDK4 | |
| SCHEMBL1447236 | 0.95 | CDK2 (0.83) | CDK2CDK1KCNH2CCNT1CDK4 | |
| SCHEMBL1447182 | 0.95 | CDK2 (0.83) | CDK2CDK1KCNH2CCNT1CDK4 | |
| SCHEMBL1447954 | 0.91 | CDK2 (0.80) | CDK2CDK1KCNH2CCNT1CDK4 | |
| SCHEMBL1448494 | 0.88 | CDK2 (0.77) | CDK2CDK1KCNH2IKBKBCHUK | |
| SCHEMBL1447682 | 0.88 | CDK2 (1.00) | CDK2CDK1KCNH2CDK4 | |
| SCHEMBL1447139 | 0.87 | CDK2 (0.75) | CDK2CDK1KCNH2CCNT1CDK4 | |
| SCHEMBL1447627 | 0.87 | CDK2 (0.81) | CDK2CDK1KCNH2CCNT1CDK4 | |
| SCHEMBL1448907 | 0.87 | CDK2 (0.81) | CDK2CDK1KCNH2CCNT1CDK4 | |
| SCHEMBL1447874 | 0.87 | CDK2 (0.81) | CDK2CDK1KCNH2CCNT1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301928-A1 | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |