Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | REN | P00797 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17158249 | 0.88 | KDM1A (0.49) | NAMPTRENKDM1AHDAC1HDAC6 | |
| SCHEMBL7633049 | 0.87 | MCL1 (0.46) | NAMPTKDM1ABCHENOTUMMAPT | |
| SCHEMBL17158286 | 0.85 | PDE4B (0.42) | NAMPTKDM1AHDAC1HDAC6BCHE | |
| SCHEMBL6648174 | 0.81 | NOTUM (0.47) | NAMPTKDM1AHDAC1HDAC6BCHE | |
| SCHEMBL16353667 | 0.81 | NOTUM (0.47) | NAMPTKDM1AHDAC1HDAC6BCHE | |
| SCHEMBL14587286 | 0.81 | KDM1A (0.46) | NAMPTKDM1AHDAC1HDAC6BCHE | |
| SCHEMBL14587287 | 0.81 | KDM1A (0.46) | NAMPTKDM1AHDAC1HDAC6BCHE | |
| SCHEMBL16385108 | 0.81 | NOTUM (0.47) | NAMPTKDM1AHDAC1HDAC6BCHE | |
| SCHEMBL16353535 | 0.81 | NOTUM (0.47) | NAMPTKDM1AHDAC1HDAC6BCHE | |
| SCHEMBL23228659 | 0.81 | USP30 (0.43) | KDM1AHDAC1HDAC6BCHENOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137371-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-05-18 | — | — | US | disclosed |
| US-20170137371-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-05-18 | — | — | US | disclosed |
| US-9598371-B2 | Arylalkylamine compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-03-21 | — | — | US | disclosed |
| US-9598371-B2 | Arylalkylamine compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-03-21 | — | — | US | disclosed |
| US-9598371-B2 | Arylalkylamine compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-03-21 | — | — | US | disclosed |
| US-20160075655-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-03-17 | — | — | US | disclosed |
| US-20160075655-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-03-17 | — | — | US | disclosed |
| US-9227919-B2 | Arylalkylamine compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2016-01-05 | — | — | US | disclosed |
| US-9227919-B2 | Arylalkylamine compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2016-01-05 | — | — | US | disclosed |
| US-9227919-B2 | Arylalkylamine compounds as calcium sensing receptor modulators | LUPIN LIMITED (IN) | 2016-01-05 | — | — | US | disclosed |
| US-20090312341-A1 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A HETEROCYCLIC SUBSTITUENT | SCHERING CORPORATION | 2009-12-17 | — | — | US | disclosed |
| US-7598250-B2 | Cyclic amine BACE-1 inhibitors having a heterocyclic substituent | SCHERING CORPORATION (US) | 2009-10-06 | — | — | US | disclosed |
| EP-1660443-B1 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT | SCHERING CORP (US) | 2009-03-04 | — | — | EP | disclosed |
| EP-1660447-B1 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A HETEROCYCLIC SUBSTITUENT | SCHERING CORP (US) | 2008-07-30 | — | — | EP | disclosed |
| EP-1660447-A1 | CYCLIC AMINE BASE-1 INHIBITORS HAVING A HETEROCYCLIC SUBSTITUENT | SCHERING CORPORATION (US) | 2006-05-31 | — | — | EP | disclosed |
| EP-1660443-A2 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT | SCHERING CORPORATION (US) | 2006-05-31 | — | — | EP | disclosed |
| US-20050119227-A1 | Cyclic amine bace-1 inhibitors having a benzamide substituent | SCHERING CORPORATION | 2005-06-02 | — | — | US | disclosed |
| WO-2005016876-A2 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT | SCHERING CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| US-20050043290-A1 | Cyclic amine BACE-1 inhibitors having a heterocyclic substituent | SCHERING CORPORATION AND PHARMACOPEIA DRUG DISCOVERY INC. | 2005-02-24 | — | — | US | disclosed |
| WO-2005014540-A1 | CYCLIC AMINE BASE-1 INHIBITORS HAVING A HETEROCYCLIC SUBSTITUENT | SCHERING CORPORATION (US) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043290-A1 | Cyclic amine BACE-1 inhibitors having a heterocyclic substituent | BACE1, BACE2, PSEN1 | NAMPT 4415/4885REN 251/4885KDM1A 2655/4885 |
| US-20050119227-A1 | Cyclic amine bace-1 inhibitors having a benzamide substituent | BACE1, BACE2, BCHE | NAMPT 1756/4885REN 1130/4885KDM1A 757/4885 |
| US-20090312341-A1 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A HETEROCYCLIC SUBSTITUENT | BACE1, BACE2, PSEN1 | NAMPT 4415/4885REN 251/4885KDM1A 2655/4885 |
| US-20170137371-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR2, ORAI1 | NAMPT 3418/4885REN 829/4885KDM1A 2847/4885 |
| US-20160075655-A1 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR2, ORAI1 | NAMPT 3418/4885REN 829/4885KDM1A 2847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.