Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448481 | 1.00 | KMT2A (0.45) | KMT2AMEN1TP53MAPTTHRB | |
| SCHEMBL12741701 | 1.00 | KMT2A (0.45) | KMT2AMEN1TP53MAPTTHRB | |
| SCHEMBL1448459 | 0.92 | MEN1 (0.51) | KMT2AMEN1TP53MAPTTHRB | |
| SCHEMBL12741607 | 0.92 | MEN1 (0.51) | KMT2AMEN1TP53MAPTTHRB | |
| SCHEMBL1448460 | 0.92 | MEN1 (0.51) | KMT2AMEN1TP53MAPTTHRB | |
| SCHEMBL12741699 | 0.89 | HPGD (0.44) | KMT2AMEN1MAPTNPSR1KDM4E | |
| SCHEMBL12741742 | 0.87 | MEN1 (0.42) | KMT2AMEN1NPSR1L3MBTL1P2RX7 | |
| SCHEMBL1448445 | 0.81 | MEN1 (0.35) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL1448444 | 0.81 | MEN1 (0.35) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL12900485 | 0.80 | MEN1 (0.38) | KMT2AMEN1NPSR1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2017-01-12 | — | — | US | disclosed |
| US-20150111851-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2015-04-23 | — | — | US | disclosed |
| US-8916579-B2 | 5-fluoropyrimidinone derivatives | DOW AGROSCIENCES, LLC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-20110053891-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, CASP5, CYP3A5 | KMT2A 3314/4885MEN1 2898/4885TP53 2303/4885 |
| US-20150111851-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, CASP5, CYP3A5 | KMT2A 3314/4885MEN1 2898/4885TP53 2303/4885 |
| US-20110053891-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, CASP5, CYP3A5 | KMT2A 3314/4885MEN1 2898/4885TP53 2303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.