SCHEMBL14485381

SCHEMBL14485381

N[C@H](CO)Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PCNA P12004 14/20 1.00
▸ LIG1 P18858 1/20 1.00
▸ THRB P10828 5/20 0.51
▸ THRA P10827 3/20 0.51
▸ LMNA P02545 3/20 0.51
▸ MEN1 O00255 2/20 0.51
▸ KMT2A Q03164 2/20 0.51
▸ CYP2D6 P10635 1/20 0.51
▸ TSHR P16473 1/20 0.51
▸ GABRP O00591 1/20 0.51
▸ GABRD O14764 1/20 0.51
▸ ABCB11 O95342 1/20 0.51
▸ F2 P00734 1/20 0.51
▸ GABRA1 P14867 1/20 0.51
▸ GABRB1 P18505 1/20 0.51
▸ GABRG2 P18507 1/20 0.51
▸ GABRB3 P28472 1/20 0.51
▸ ADORA1 P30542 1/20 0.51
▸ GABRA5 P31644 1/20 0.51
▸ GABRA3 P34903 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14485176 1.00 PCNA (1.00) PCNALIG1THRBTHRALMNA
SCHEMBL14485173 1.00 PCNA (1.00) PCNALIG1THRBTHRALMNA
SCHEMBL22382798 0.91 PCNA (0.83) PCNALIG1THRBTHRALMNA
SCHEMBL14484721 0.89 PCNA (0.80) PCNALIG1THRBTHRALMNA
SCHEMBL14484719 0.89 PCNA (0.80) PCNALIG1THRBTHRALMNA
SCHEMBL16124416 0.89 PCNA (0.80) PCNALIG1THRBTHRALMNA
SCHEMBL16124414 0.87 PCNA (0.78) PCNALIG1THRBTHRALMNA
SCHEMBL16124477 0.87 PCNA (0.78) PCNALIG1THRBTHRALMNA
SCHEMBL16124413 0.87 PCNA (0.78) PCNALIG1THRBTHRALMNA
SCHEMBL16124462 0.86 PCNA (0.76) PCNALIG1THRBTHRALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4733383-A1 CULTURE MEDIUM AND BLOOD CELL CLONE, AND METHOD FOR PRODUCING SAME Japan Institute for Health Security (JP) 2026-04-29 — — EP claimed
CN-119326903-A Combined use of PCNA inhibitor and PARP1 inhibitor 兰州大学 2025-01-21 — — CN claimed
WO-2024262610-A1 CULTURE MEDIUM AND BLOOD CELL CLONE, AND METHOD FOR PRODUCING SAME 国立研究開発法人国立国際医療研究センター 2024-12-26 — — WO claimed
EP-4733383-A1 CULTURE MEDIUM AND BLOOD CELL CLONE, AND METHOD FOR PRODUCING SAME Japan Institute for Health Security (JP) 2026-04-29 — — EP disclosed
EP-4691291-A1 AEROSOL GENERATING DEVICE COMPRISING HEATER MODULE KT&G Corporation (KR) 2026-02-11 — — EP disclosed
US-12523420-B2 Refrigerator LG ELECTRONICS INC. (KR) 2026-01-13 — — US disclosed
US-12487022-B2 Refrigerator LG ELECTRONICS INC. (KR) 2025-12-02 — — US disclosed
EP-3349754-B9 PCNA INHIBITORS HOPE CITY (US) 2025-10-22 — — EP disclosed
US-12449193-B2 Refrigerator LG ELECTRONICS INC. (KR) 2025-10-21 — — US disclosed
US-12435030-B2 PCNA inhibitors CITY OF HOPE (US) 2025-10-07 — — US disclosed
EP-4616910-A2 PCNA INHIBITORS City of Hope (US) 2025-09-17 — — EP disclosed
US-10758588-B2 Inhibitors for proliferating cell nuclear antigen and uses PURDUE RESEARCH FOUNDATION (US) 2020-09-01 — — US disclosed
US-10758588-B2 Inhibitors for proliferating cell nuclear antigen and uses PURDUE RESEARCH FOUNDATION (US) 2020-09-01 — — US disclosed
US-20180360905-A1 INHIBITORS FOR PROLIFERATING CELL NUCLEAR ANTIGEN AND USES PURDUE RESEARCH FOUNDATION (US) 2018-12-20 — — US disclosed
WO-2017100154-A1 INHIBITORS FOR PROLIFERATING CELL NUCLEAR ANTIGEN AND USES PURDUE RESEARCH FOUNDATION (US) 2017-06-15 — — WO disclosed
WO-2017100154-A1 INHIBITORS FOR PROLIFERATING CELL NUCLEAR ANTIGEN AND USES PURDUE RESEARCH FOUNDATION (US) 2017-06-15 — — WO disclosed
US-20140288077-A1 SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2014-09-25 — — US disclosed
US-20140288077-A1 SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2014-09-25 — — US disclosed
US-20140288077-A1 SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2014-09-25 — — US disclosed
WO-2013006734-A1 SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2013-01-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180360905-A1 INHIBITORS FOR PROLIFERATING CELL NUCLEAR ANTIGEN AND USES MKI67, PCNA, PCLAF PCNA 2/4885LIG1 1241/4885THRB 3996/4885
US-12435030-B2 PCNA inhibitors PCNA, MKI67, PCLAF PCNA 1/4885LIG1 143/4885THRB 3775/4885
US-20140288077-A1 SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY MKI67, PCNA, PCLAF PCNA 2/4885LIG1 1098/4885THRB 2853/4885
US-10758588-B2 Inhibitors for proliferating cell nuclear antigen and uses MKI67, PCNA, PCLAF PCNA 2/4885LIG1 1241/4885THRB 3996/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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