Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 1.00 |
| ▸ | MMP1 | P03956 | 2/20 | 0.56 |
| ▸ | FCER2 | P06734 | 2/20 | 0.56 |
| ▸ | KLK1 | P06870 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21669886 | 0.91 | KLKB1 (0.83) | KLKB1MMP1FCER2KLK1 | |
| SCHEMBL14485442 | 0.91 | KLKB1 (0.83) | KLKB1MMP1FCER2KLK1 | |
| SCHEMBL14485877 | 0.90 | KLKB1 (0.82) | KLKB1MMP1FCER2KLK1 | |
| SCHEMBL14485873 | 0.90 | KLKB1 (0.82) | KLKB1MMP1FCER2KLK1 | |
| SCHEMBL15900904 | 0.88 | KLKB1 (0.78) | KLKB1MMP1FCER2KLK1 | |
| SCHEMBL14485616 | 0.88 | KLKB1 (0.78) | KLKB1MMP1FCER2KLK1 | |
| SCHEMBL14485892 | 0.87 | KLKB1 (0.77) | KLKB1MMP1FCER2KLK1 | |
| SCHEMBL15901046 | 0.87 | KLKB1 (0.77) | KLKB1MMP1FCER2KLK1 | |
| Trifluoroacetic Acid SCHEMBL15900948 | 0.87 | KLKB1 (0.77) | KLKB1MMP1FCER2KLK1 | |
| SCHEMBL14486255 | 0.86 | KLKB1 (0.76) | KLKB1MMP1FCER2KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729443-B3 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-02-12 | — | — | EP | disclosed |
| EP-2729443-B1 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2015-11-25 | — | — | EP | disclosed |
| EP-2729443-A1 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2014-05-14 | — | — | EP | disclosed |
| WO-2013005045-A1 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2013-01-10 | — | — | WO | disclosed |