Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.68 |
| ▸ | CDK1 | P06493 | 7/20 | 0.68 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.57 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447431 | 0.97 | CDK2 (0.66) | CDK2KCNH2CDK1CSF1RCDK4 | |
| SCHEMBL1447250 | 0.92 | KCNH2 (0.68) | CDK2KCNH2CDK1CSF1RCDK4 | |
| SCHEMBL1447739 | 0.91 | CDK2 (0.63) | CDK2KCNH2CDK1CSF1RCDK4 | |
| SCHEMBL1447239 | 0.91 | CDK2 (0.82) | CDK2KCNH2CDK1 | |
| SCHEMBL1447906 | 0.91 | CDK2 (0.82) | CDK2KCNH2CDK1 | |
| SCHEMBL1447727 | 0.91 | CDK2 (0.62) | CDK2KCNH2CDK1CSF1RCDK4 | |
| SCHEMBL1447867 | 0.90 | CDK2 (0.62) | CDK2KCNH2CDK1CSF1RCDK4 | |
| SCHEMBL1447591 | 0.88 | CDK2 (0.84) | CDK2KCNH2CDK1 | |
| SCHEMBL1447572 | 0.88 | CDK2 (0.78) | CDK2KCNH2CDK1 | |
| SCHEMBL1447655 | 0.86 | CDK2 (0.80) | CDK2KCNH2CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301928-A1 | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |