Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.64 |
| ▸ | CDK1 | P06493 | 6/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.61 |
| ▸ | CDK4 | P11802 | 3/20 | 0.60 |
| ▸ | CDKL1 | Q00532 | 1/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CCND1 | P24385 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CCND3 | P30281 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29431926 | 0.97 | CDK2 (0.61) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1448376 | 0.97 | CDK2 (0.61) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1446871 | 0.93 | CDK2 (0.67) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1447605 | 0.91 | CDK2 (0.75) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1447688 | 0.90 | KCNH2 (0.73) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1448629 | 0.89 | CDK2 (0.63) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1448354 | 0.89 | CDK2 (0.62) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1447419 | 0.88 | CDK2 (0.61) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1448097 | 0.88 | CDK2 (0.71) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1447436 | 0.87 | KCNH2 (0.69) | CDK2CDK1KCNH2CDK4CDKL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301928-A1 | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |