Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.79 |
| ▸ | PDGFRA | P16234 | 12/20 | 0.79 |
| ▸ | BCR | P11274 | 8/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.79 |
| ▸ | EGFR | P00533 | 2/20 | 0.79 |
| ▸ | PRKCA | P17252 | 1/20 | 0.79 |
| ▸ | KIT | P10721 | 4/20 | 0.72 |
| ▸ | JAK3 | P52333 | 1/20 | 0.68 |
| ▸ | BTK | Q06187 | 1/20 | 0.68 |
| ▸ | ITK | Q08881 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.68 |
| ▸ | ABL2 | P42684 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004455 | 0.89 | PDGFRA (0.91) | ABL1PDGFRABCRPDGFRBEGFR | |
| SCHEMBL9782 | 0.88 | PDGFRA (1.00) | ABL1PDGFRABCRPDGFRBEGFR | |
| SCHEMBL29498750 | 0.88 | PDGFRA (1.00) | ABL1PDGFRABCRPDGFRBEGFR | |
| SCHEMBL4801110 | 0.88 | ABL1 (0.84) | ABL1PDGFRABCRPDGFRBEGFR | |
| Methane SCHEMBL5972158 | 0.87 | PDGFRA (0.98) | ABL1PDGFRABCRPDGFRBEGFR | |
| SCHEMBL4803263 | 0.86 | ABL1 (0.81) | ABL1PDGFRABCRPDGFRBEGFR | |
| SCHEMBL4802851 | 0.86 | ABL1 (0.83) | ABL1PDGFRABCRPDGFRBEGFR | |
| SCHEMBL9820 | 0.86 | PDGFRA (1.00) | ABL1PDGFRABCRPDGFRBEGFR | |
| SCHEMBL3099865 | 0.85 | ABL1 (0.77) | ABL1PDGFRABCRPDGFRBEGFR | |
| SCHEMBL1408815 | 0.85 | ABL1 (0.77) | ABL1PDGFRABCRPDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7232825-B2 | Phenylaminopyrimidine derivatives and methods of use | CHEN GUOQING P | 2007-06-19 | — | — | US | disclosed |
| US-7232825-B2 | Phenylaminopyrimidine derivatives and methods of use | CHEN GUOQING P | 2007-06-19 | — | — | US | disclosed |