Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 3/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA7 | P43166 | 2/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.55 |
| ▸ | SLC28A3 | Q9HAS3 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29788611 | 1.00 | MAOB (0.61) | MAOBTHRBCA9CA12CA1 | |
| SCHEMBL5088087 | 0.89 | CA9 (0.54) | MAOBTHRBCA9MAPTGAA | |
| SCHEMBL12009587 | 0.87 | MAOB (0.63) | MAOBTHRBCA9CA12CA1 | |
| SCHEMBL7648612 | 0.86 | MAOB (0.58) | MAOBTHRBCA9CA12CA1 | |
| SCHEMBL5464526 | 0.86 | CA12 (0.55) | MAOBCA9CA12CA1CA2 | |
| SCHEMBL16160517 | 0.85 | PTPN1 (0.60) | MAOBTHRBCA9CA12CA1 | |
| SCHEMBL15012848 | 0.84 | CA12 (0.54) | MAOBTHRBCA9CA12CA1 | |
| SCHEMBL23640216 | 0.83 | MAOB (0.52) | MAOBTHRBCA9CA12CA1 | |
| SCHEMBL10066978 | 0.83 | CA12 (0.77) | MAOBCA9CA12CA1CA2 | |
| SCHEMBL19064581 | 0.83 | CA12 (0.67) | MAOBCA9CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200330410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2020-10-22 | — | — | US | disclosed |
| EP-2373758-B1 | PHOTOCHROMIC OPTICAL ARTICLES PREPARED WITH REVERSIBLE THERMOCHROMIC MATERIALS | TRANSITIONS OPTICAL INC (US) | 2017-05-10 | — | — | EP | disclosed |
| US-8547625-B2 | Photochromic optical articles prepared with reversible thermochromic materials | TRANSITIONS OPTICAL, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| EP-2373758-A1 | PHOTOCHROMIC OPTICAL ARTICLES PREPARED WITH REVERSIBLE THERMOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2011-10-12 | — | — | EP | disclosed |
| US-7911676-B2 | Photochromic optical articles prepared with reversible thermochromic materials | TRANSITIONS OPTICAL, INC. (US) | 2011-03-22 | — | — | US | disclosed |
| US-20110051223-A1 | PHOTOCHROMIC OPTICAL ARTICLES PREPARED WITH REVERSIBLE THERMOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (FL) | 2011-03-03 | — | — | US | disclosed |
| WO-2010074969-A1 | PHOTOCHROMIC OPTICAL ARTICLES PREPARED WITH REVERSIBLE THERMOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20100149620-A1 | PHOTOCHROMIC OPTICAL ARTICLES PREPARED WITH REVERSIBLE THERMOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200330410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | MAOB 1723/4885THRB 659/4885CA9 3620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.